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Welcome to VirusFolds

A unified platform for exploring predicted protein structures, homologs, and interaction clusters of large DNA viruses.

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Jump directly to the main datasets or browse the networks and cluster maps.

HerpesFolds HerpesClusters HerpesPPIs PoxFolds PoxClusters PoxPPIs AdenoFolds AdenoClusters AdenoPPIs

Explore the Folds

Proteome-wide structure predictions for all nine human herpesviruses and animal models – clusters, homologs and interaction networks.

Structural resources for poxviruses, including homolog mapping and protein interaction clusters.

Predicted protein structures and homolog groups across adenoviruses, enabling comparative structural virology.

About VirusFolds

VirusFolds unites HerpesFolds, PoxFolds and AdenoFolds into one hub.

Based on AlphaFold structure predictions and similarity searches with FoldSeek, VirusFolds provides interactive access to structural homologs and clusters. For details on the herpesvirus dataset, see the publication by Timothy Soh et al.: A proteome-wide structural systems approach reveals insights into protein families of all human herpesviruses .

VirusFolds is a project by the Bosse Lab, developed in collaboration with multiple contributors.

Need help getting started?

Visit our Tutorial & Help page for examples, videos, and detailed explanations on how to interpret AlphaFold predictions.