Explore predicted protein-protein interactions across adenovirus genomes. Select genomes, adjust confidence thresholds, and compare their interaction networks.
Choose the datasets to include, then compare shared interactions or interactions specific to Group A. Confidence thresholds can be adjusted under Advanced Filters.
Every protein of each adenovirus genome was predicted against every other with LocalColabFold / AlphaFold Multimer. Selecting several genomes shows what their predicted networks have in common, with the proteins named after whichever genome is chosen as the reference.
Use the selection board above to generate and compare networks. Shared interactions are present in every selected Group A dataset. Differential interactions are present in all Group A datasets but absent from Group B.
Click and drag to move around the network, use the mouse wheel to zoom, click nodes to explore proteins, and click edges to inspect interactions.
| Dataset | Evidence Type | Viruses | Weight Metric | Source |
|---|---|---|---|---|
| HAdV-C5-AY339865-1 — all vs all | Other |
HAdV-C5-AY339865-1
|
AF-multimer | AF-multimer |
| HAdV-C5-AY601635-1 — all vs all | Other |
HAdV-C5-AY601635-1
|
AF-multimer | AF-multimer |
| HAdV-41-DQ315364-2 — all vs all | Other |
HAdV-41-DQ315364-2
|
AF-multimer | AF-multimer |
Predictions were run with LocalColabFold on the DESY compute cluster.
Molecular visualization uses Mol* Viewer with JSmol as a fallback when WebGL is unavailable.
The interaction network is rendered using Cytoscape.js for graph visualization and analysis.
See also: Mirdita, M. et al. (2022). ColabFold: making protein folding accessible to all. GitHub
This software is licensed under the GNU General Public License v3.0.
You may redistribute and/or modify it under the terms of the GPL as published by the Free Software Foundation, version 3 or later. Read the full license text