Explore predicted and experimentally validated protein-protein interactions across human herpesviruses. Select datasets, adjust confidence thresholds, and compare interaction networks.
Choose the datasets to include, then compare shared interactions or interactions specific to Group A. Confidence thresholds can be adjusted under Advanced Filters.
LocalColabFold / AlphaFold Multimer predicted protein-protein dimer interactions are integrated with experimental and curated source datasets for comparison.
| Virus | Strain | UniProt Proteome |
|---|---|---|
| HSV-1 | Strain 17 | UP000009294 |
| HCMV | Strain Merlin | UP000000938 |
| KSHV | Strain GK18 | UP000000942 |
| VZV | Strain Dumas | UP000002602 |
Use the selection board above to generate and compare networks. Shared interactions are present in every selected Group A dataset. Differential interactions are present in all Group A datasets but absent from Group B.
Click and drag to move around the network, use the mouse wheel to zoom, click nodes to explore proteins, and click edges to inspect interactions.
| Dataset | Evidence Type | Viruses | Weight Metric | Source |
|---|---|---|---|---|
| HSV-1 / HSV-1 — Cross-Link Bogdanow-2025 | Cross-linking MS |
HSV-1
|
Cross-Link | Bogdanow 2025 |
| HSV-1 / HSV-1 — HVINT2 Duran-2019 | Two-hybrid screen |
HSV-1
|
HVINT2 | Duran 2019 |
| HSV-1 / HSV-1 — HerpesPPIs Soh-2024 | Structure prediction |
HSV-1
|
HerpesPPIs | Soh 2024 |
| HSV-1 / HSV-1 — IntAct | Curated database |
HSV-1
|
IntAct | IntAct |
| HSV-1 / HSV-1 — LUCIA Zhang-Kraft-Soh | Luciferase assay |
HSV-1
|
LUCIA_Zhang-Kraft-Soh | LUCIA_Zhang-Kraft-Soh |
| HSV-1 / HSV-1 — MINT | Curated database |
HSV-1
|
MINT | MINT |
| HSV-1 / Human — Cross-Link Bogdanow-2025 | Cross-linking MS |
HSV-1
Human
|
Cross-Link | Bogdanow 2025 |
| HSV-1 / Human — IntAct | Curated database |
HSV-1
Human
|
IntAct | IntAct |
| HSV-1 / Human — MINT | Curated database |
HSV-1
Human
|
MINT | MINT |
| VZV / Human — IntAct | Curated database |
VZV
Human
|
IntAct | IntAct |
| VZV / VZV — HerpesPPIs Soh-2024 | Structure prediction |
VZV
|
HerpesPPIs | Soh 2024 |
| VZV / VZV — IntAct | Curated database |
VZV
|
IntAct | IntAct |
| VZV / VZV — MINT | Curated database |
VZV
|
MINT | MINT |
| HCMV / HCMV — HVINT2 Duan-2019 | Two-hybrid screen |
HCMV
|
HVINT2 | Duan 2019 |
| HCMV / HCMV — HerpesPPIs Soh-2024 | Structure prediction |
HCMV
|
HerpesPPIs | Soh 2024 |
| HCMV / HCMV — IntAct | Curated database |
HCMV
|
IntAct | IntAct |
| HCMV / Human — IntAct | Curated database |
HCMV
Human
|
IntAct | IntAct |
| HCMV / Human — MINT | Curated database |
HCMV
Human
|
MINT | MINT |
| EBV / EBV — HVINT2 Duran-2019 | Two-hybrid screen |
EBV
|
HVINT2 | Duran 2019 |
| EBV / EBV — IntAct | Curated database |
EBV
|
IntAct | IntAct |
| EBV / EBV — MINT | Curated database |
EBV
|
MINT | MINT |
| EBV / Human — IntAct | Curated database |
EBV
Human
|
IntAct | IntAct |
| EBV / Human — MINT | Curated database |
EBV
Human
|
MINT | MINT |
| KSHV / KSHV — HerpesPPIs Soh-2024 | Structure prediction |
KSHV
|
HerpesPPIs | Soh 2024 |
This resource is the result of over 100,000 predicted models and several months of computing time. If you use HerpesPPIs in your work, please cite:
Soh, T., & Bosse, J. (2024). HerpesFolds: All-versus-all protein interaction network [Data set]. Zenodo. https://doi.org/10.5281/zenodo.12517508 Predictions were run with LocalColabFold on the DESY compute cluster.
Molecular visualization uses Mol* Viewer with JSmol as a fallback when WebGL is unavailable.
The interaction network is rendered using Cytoscape.js for graph visualization and analysis.
See also: Mirdita, M. et al. (2022). ColabFold: making protein folding accessible to all. GitHub
This software is licensed under the GNU General Public License v3.0.
You may redistribute and/or modify it under the terms of the GPL as published by the Free Software Foundation, version 3 or later. Read the full license text